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Anti-NOX4 Antibody UOTR1B493


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SKU Description Amount Price Availability*  
TA307574 Rabbit monoclonal antibody against NOX4(clone UOTR1B493) 100ul $379 In Stock
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OriGene Data

ImmunogenGenerated against a peptide sequence within the NADPH binding domain of human NOX4. This sequence is conserved between human and mouse NOX4. As mentioned in Lee et al., Circ. Research 106, March 2010.
Clone NameUOTR1B493 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsIHC-Fr: Use at an assay dependent concentration; WB: 1:1000 - 1:5000; IHC-P: 1:100 - 1:250; ICC/IF: Use at an assay dependent concentration
Predicted MW Explanation 67 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens NADPH oxidase 4 (NOX4), transcript variant NOX4B
Alternative NameKOX; KOX-1; RENOX
Database LinkNP_001137308
Entrez Gene 50507 Human
Entrez Gene 50490 Mouse
Entrez Gene 85431 Rat
FunctionNOX4 is a member of the NOX-family of enzymes that functions as the catalytic subunit of the NADPH oxidase complex. It is localized to non-phagocytic cells, where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by NOX4 have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. Similar to gp91-phox, the enzymatic activity of Nox4 produces superoxide anions. In vascular cells, the addition of angiotensin II increases Nox4 expression, which suggests a role for Nox-4 in vascular oxidative stress response.
Related PathwayTransmembraneDruggable Genome

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-NOX4 antibody [UOTR1B493]; All lanes : Anti-NADPH oxidase 4 antibody [UOTR1B493] at 1/1000 dilution.Lane 1 : Fetal kidney cell lysates.Lane 2 : U87-MG cell lysates.Lane 3 : 293 cell lysates.Lane 4 : JAR cell lysates.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 67 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOX4 antibody [UOTR1B493]; Immunohistochemical analysis of paraffin embedded Human fetal kidney tissue labelled with TA307574 at 1/100 dilution.
Immunohistochemistry (Frozen sections) - Anti-NOX4 antibody [UOTR1B493]; Immunohistochemical analysis of frozen rat lung tissue taken from rats with monocrotaline-exposure/pneumonectomy, staining NOX4 with TA307574.


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