OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-NOX4 antibodies

Anti-NOX4 Antibody UOTR1B493

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307574
  • Rabbit monoclonal antibody against NOX4(clone UOTR1B493)
100ul $379 In Stock
Add to Shopping Cart
WB(1)
IHC(2)

OriGene Data

ImmunogenGenerated against a peptide sequence within the NADPH binding domain of human NOX4. This sequence is conserved between human and mouse NOX4. As mentioned in Lee et al., Circ. Research 106, March 2010.
Clone NameUOTR1B493 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsIHC-Fr: Use at an assay dependent concentration; WB: 1:1000 - 1:5000; IHC-P: 1:100 - 1:250; ICC/IF: Use at an assay dependent concentration
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens NADPH oxidase 4 (NOX4), transcript variant 2
Alternative NameKOX; KOX-1; RENOX
Database LinkNP_001137308
FunctionNOX4 is a member of the NOX-family of enzymes that functions as the catalytic subunit of the NADPH oxidase complex. It is localized to non-phagocytic cells, where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by NOX4 have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. Similar to gp91-phox, the enzymatic activity of Nox4 produces superoxide anions. In vascular cells, the addition of angiotensin II increases Nox4 expression, which suggests a role for Nox-4 in vascular oxidative stress response.
Related Pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-NOX4 antibody [UOTR1B493]; All lanes : Anti-NADPH oxidase 4 antibody [UOTR1B493] at 1/1000 dilution.Lane 1 : Fetal kidney cell lysates.Lane 2 : U87-MG cell lysates.Lane 3 : 293 cell lysates.Lane 4 : JAR cell lysates.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 67 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOX4 antibody [UOTR1B493]; Immunohistochemical analysis of paraffin embedded Human fetal kidney tissue labelled with TA307574 at 1/100 dilution.
IHC Image
Immunohistochemistry (Frozen sections) - Anti-NOX4 antibody [UOTR1B493]; Immunohistochemical analysis of frozen rat lung tissue taken from rats with monocrotaline-exposure/pneumonectomy, staining NOX4 with TA307574.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title