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Home Antibody All anti-NOTCH1 antibodies

Anti-NOTCH1 TRUEMAB Antibody Clone OTI4C9

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500248 anti-Notch1 mouse monoclonal antibody, clone OTI4C9 (formerly 4C9) 100ul $325 In Stock
LC402602 NOTCH1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500248 Carrier-free (BSA/glycerol-free) Notch1 mouse monoclonal antibody, clone OTI4C9 (formerly 4C9) 100ug $450 3-4 weeks
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WB(1)
IHC(15)

OriGene Data

ImmunogenRecombinant protein expressed in E.coli corresponding to amino acids 2300-2556 of human NOTCH1
Clone NameClone OTI4C9 IsotypeIgG2b
Species ReactivityHuman Concentration0.7 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:1000, IHC: 1:50-1:150
Predicted MW Explanation 270.6 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Puridied form mouse ascites fluids

Reference Data

Target NameHomo sapiens notch 1 (NOTCH1)
Alternative NameAOS5; AOVD1; hN1; TAN1
Database LinkNP_060087
Entrez Gene 4851 Human
FunctionNotch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development
Related PathwayStem cell relevant signaling - DSL/Notch pathwayES Cell Differentiation/IPSAdult stem cellsCancer stem cellsDruggable Genome Dorso-ventral axis formationNotch signaling pathwayPrion diseases

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NOTCH1 (RC211365, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NOTCH1.
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Immunohistochemical staining of paraffin-embedded breast tissue within the normal limits using anti-NOTCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-NOTCH1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-NOTCH1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-NOTCH1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-NOTCH1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Carcinoma of lung tissue using anti-NOTCH1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-NOTCH1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded pancreas tissue within the normal limits using anti-NOTCH1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas tissue using anti-NOTCH1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Carcinoma of thyroid tissue using anti-NOTCH1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded endometrium tissue within the normal limits using anti-NOTCH1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500248, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-NOTCH1 mouse monoclonal antibody. (TA500248)
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Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-NOTCH1 mouse monoclonal antibody. (TA500248)
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Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-NOTCH1 mouse monoclonal antibody. (TA500248)
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Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-NOTCH1 mouse monoclonal antibody. (TA500248)
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