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Home Antibody All anti-NOTCH1 antibodies

Anti-NOTCH1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA321861
  • Anti-NOTCH1 Rabbit Polyclonal Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402602) , 20ug
100ul 325 2-3 Weeks
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WB(1)
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Also for NOTCH1 (NM_017617)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to a region derived from 2541-2555 amino acids of human notch 1
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.7mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:1000-2000, WB: 1:200-1000
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens notch 1 (NOTCH1)
Alternative NamehN1; TAN1
Database LinkNP_060087
FunctionThis gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
Related Pathway
Delta-Notch Signaling Pathway

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WB Image
Predicted band size: 273 kDa . Positive control: HT-29 cell lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 60 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

 

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