Search:     All Products Assays Human cDNA clone, untagged Human cDNA clone, tagged RNAi 3'-UTR Clone Human Primer Mouse cDNA clone, untagged Mouse cDNA clone, tagged Rat ORF clone, untagged Rat ORF clone, tagged Virus ORF clone, tagged Mouse Primer qPCR Standard Proteins Mass Spec Standard Antibodies Lysate MicroRNA Expression Plasmids MicroRNA primer pairs MicroRNA template standards Other Products

 

Antibody

UltraMAB IHC Antibodies

TrueMAB Primary Antibodies

Anti-tag Antibodies

ELISA Antibodies

Luminex Antibodies

Secondary Antibodies

Antibody Accessories

Antibody Service

 

Related Products

 

Useful Links

FAQs

Anti-NONO Antibody EPR5269

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human p54nrb was used as an immunogen.
Clone Name	EPR5269	Isotype
Species Reactivity	Human, Mouse	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:1,000 - 10,000;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens non-POU domain containing, octamer-binding (NONO), transcript variant 1
Alternative Name	NMT55; NRB54; P54; P54NRB
Database Link	NP_001138880
Function	p54nrb (NONO) is a DNA- and RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing (1). As part of the splicesomal complex, PTB-associated RNA splicing factor (PSF) and p54nrb are essential for both step I and II pre-mRNA splicing reactions (2). p54nrb is a component of the SFPQ-NONO complex, which is associated with MATR3 and plays a role in nuclear retention of defective RNA’s. The complex is involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (3). A rearrangement between p54nrb and the transcription factor E3 has been observed in papillary renal cell carcinoma (1).
Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of non-POU domain containing, octamer-binding (NONO), transcript variant 1 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • NONO - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • NONO - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Nono - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • NONO - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Nono - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens non-POU domain containing, octamer-binding (NONO), transcript variant 1 as transfection-ready DNA • Lenti ORF clone of Human non-POU domain containing, octamer-binding (NONO), transcript variant 1 , Myc-DDK-tagged • GFP-tagged ORF clone of Homo sapiens non-POU domain containing, octamer-binding (NONO), transcript variant 1 as transfection-ready DNA • Lenti ORF clone of Human non-POU domain containing, octamer-binding (NONO), transcript variant 1, mGFP tagged Related cDNA Clones • Homo sapiens non-POU domain containing, octamer-binding (NONO), transcript variant 1, mRNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)