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Home Antibody All anti-NONO antibodies

Anti-NONO Antibody EPR5269

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA311009 Rabbit Monoclonal antibody against p54nrb (NONO) 100ul $325 In Stock
LC428867 NONO HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
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Also for NONO (NM_001145408)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human p54nrb was used as an immunogen.
Clone NameEPR5269 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:50 - 1:100; ICC: 1:50 - 1:100; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens non-POU domain containing, octamer-binding (NONO), transcript variant 1
Alternative NameNMT55; NRB54; P54; P54NRB; PPP1R114
Database LinkNP_001138880
Entrez Gene 4841 Human
Entrez Gene 53610 Mouse
Functionp54nrb (NONO) is a DNA- and RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing (1). As part of the splicesomal complex, PTB-associated RNA splicing factor (PSF) and p54nrb are essential for both step I and II pre-mRNA splicing reactions (2). p54nrb is a component of the SFPQ-NONO complex, which is associated with MATR3 and plays a role in nuclear retention of defective RNA’s. The complex is involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (3). A rearrangement between p54nrb and the transcription factor E3 has been observed in papillary renal cell carcinoma (1).
Related PathwayTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - nmt55 / p54nrb antibody [EPR5269]; All lanes : Anti-nmt55 / p54nrb antibody [EPR5269] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : 293T cell lysate.Lane 3 : Molt-4 cell lysate.Lane 4 : PC-3 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 54 kDa.Observed band size : 54 kDa.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - nmt55 / p54nrb antibody [EPR5269]; Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using TA311009 at a dilution of 1/50.
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