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Anti-NONO Antibody EPR5269
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Also for NONO (NM_001145408)
|A synthetic peptide corresponding to residues in human p54nrb was used as an immunogen.|
||WB: 1:1,000 - 10,000;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens non-POU domain containing, octamer-binding (NONO), transcript variant 1|
|NMT55; NRB54; P54; P54NRB|
|p54nrb (NONO) is a DNA- and RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing (1). As part of the splicesomal complex, PTB-associated RNA splicing factor (PSF) and p54nrb are essential for both step I and II pre-mRNA splicing reactions (2). p54nrb is a component of the SFPQ-NONO complex, which is associated with MATR3 and plays a role in nuclear retention of defective RNA’s. The complex is involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (3). A rearrangement between p54nrb and the transcription factor E3 has been observed in papillary renal cell carcinoma (1).|
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Western blot analysis on (A) HeLa, (B) 293T, (C) Molt-4, and (D) PC-3 cell lysates using anti-p54nrb RabMAb.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using p54nrb RabMAb.