Home Antibody All anti-NOG antibodies
|A synthetic peptide corresponding to residues on human noggin was used as an immunogen.|
||Protein A purified
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500 - 1:1000; IP: 1:10; FC: 1:10
|Does not react with Mouse, Rat. Is unsuitable for ICC or IHC-P.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for ICC or IHC-P.
|Homo sapiens noggin (NOG)|
|The secreted polypeptide noggin (encoded by the Nog gene) binds and inactivates members of the transforming growth factor beta superfamily of signaling proteins (TGFbeta-FMs), such as BMP4. By diffusing through extracellular matrices more efficiently than TGFbeta-FMs, noggin may have a principal role in creating morphogenic gradients. Findings report that noggin is essential for joint formation and suggest that NOG requirements during skeletogenesis differ between species and between specific skeletal elements within species (1). Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs (2). The structure of the antagonist Noggin bound to BMP-7, shows that noggin inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors (3). |
TGF Beta Signaling Pathway
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Western blot - Noggin antibody; Anti-Noggin antibody at 1/500 dilution + 0.5ng of recombinant protein.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 26 kDa.Observed band size : 23 kDa .