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Home Antibody All anti-NOG antibodies

Anti-NOG Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300919
  • Rabbit Polyclonal Antibody against NOG
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401672) , 20ug Explanation
100ul 379 3-7 Days
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WB(1)
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Also for NOG (NM_005450)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on human noggin was used as an immunogen.
Clone Name IsotypeProtein A purified
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:1000; IP: 1:10; FC: 1:10
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC or IHC-P.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC or IHC-P.

Reference Data

Target NameHomo sapiens noggin (NOG)
Alternative NameSYM1; SYNS1
Database LinkNP_005441
Entrez Gene 9241 Human
FunctionThe secreted polypeptide noggin (encoded by the Nog gene) binds and inactivates members of the transforming growth factor beta superfamily of signaling proteins (TGFbeta-FMs), such as BMP4. By diffusing through extracellular matrices more efficiently than TGFbeta-FMs, noggin may have a principal role in creating morphogenic gradients. Findings report that noggin is essential for joint formation and suggest that NOG requirements during skeletogenesis differ between species and between specific skeletal elements within species (1). Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs (2). The structure of the antagonist Noggin bound to BMP-7, shows that noggin inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors (3).
Related PathwaySecreted ProteinDruggable Genome TGF-beta signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Noggin antibody; Anti-Noggin antibody at 1/500 dilution + 0.5ng of recombinant protein.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 26 kDa.Observed band size : 23 kDa .

 

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