Home Antibody All anti-NLRP3 antibodies
Also for NLRP3 (NM_001079821)
|NALP3 antibody was raised against a 16 amino acid peptide from near the amino terminus of human NALP3.|
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 1 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens NLR family, pyrin domain containing 3 (NLRP3), transcript variant 3|
|AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCU; MWS; NALP3; PYPAF1|
Entrez Gene 114548 Human
Entrez Gene 216799 Mouse
|NALP3, a member of Nod-like receptors, has a crucial role in inflammation and immunity and may be a proximal sensor of cellular stress and danger signals. NALP3 forms a caspase-1 activating molecular complex termed the inflammasome. The inflammasome allows activation of IL-1b, the key player of the inflammation and fever. NALP3 gene encodes a pyrin like protein which contains a pyrin domain, a nucleotide binding site (NBS) domain, and a leucine rich repeat (LRR) motif. NALP3 protein interacts with apoptosis associated speck like protein containing a CARD and may function as an inducer of apoptosis and an activator of NF-kB signaling. Defects in NALP3 have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).|
|Druggable Genome NOD-like receptor signaling pathway|
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Western blot analysis of NALP3 in K562 cell lysate with NALP3 antibody at 1 ug/mL (A) in the absence and (B) in the presence of blocking peptide.
Immunofluorescence of NALP3 in K562 cells with NALP3 antibody at 20 ug/mL.