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Home Antibody All anti-NLRC4 antibodies

Anti-NLRC4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306119
  • Rabbit Polyclonal Ipaf Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC412012) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenIpaf antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human Ipaf.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 and 2 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens NLR family, CARD domain containing 4 (NLRC4), transcript variant 1
Alternative NameCARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF
Database LinkNP_067032
Entrez Gene 58484 Human
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF-kappaB signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family (1). Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner (2,3). Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1.
Related Pathway NOD-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Ipaf in human PBL lysate with Ipaf antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/mL, respectively.
IF Image
Immunocytochemistry of Ipaf in THP-1 cells with Ipaf antibody at 10 ug/mL.

 

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