Anti-NKIRAS1 Antibody,

Also for NKIRAS1 (NM_020345)

Gene Name	Homo sapiens NFKB inhibitor interacting Ras-like 1 (NKIRAS1)
Synonyms:	kappaB-Ras1; KBRAS1
Immunogen	KappaB ras1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human KappaB ras1.
Buffer	PBS containing 0.02% sodium azide.
Clone Name		Isotype	IgG
Species Reactivity	Human, Mouse	Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column (Protein A or G Sepharose)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 0.5 - 1 ug/ml
Background	KappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody is specific for kappaB-ras1 and has no cross-reactivity to kappaB-ras2.
Related Pathway

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WB Image

Western blot analysis of KappaB ras1 in RAW264.7 cell lysate with KappaB ras1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

IHC Image

Immunocytochemistry of KappaB-ras1 in RAW264.7 cells with KappaB-ras1 antibody at 1 ug/ml.

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Anti-NKIRAS1 Antibody

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