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Home Antibody All anti-NGFR antibodies

Anti-NGFR Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306246
  • Rabbit Polyclonal NGFR Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419286) , 20ug
100ug 325 In Stock
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WB(1)
IF(1)
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Also for NGFR (NM_002507)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNGFR antibody was raised against purified recombinant human NGFR.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens nerve growth factor receptor (NGFR)
Alternative NameCD271; Gp80-LNGFR; p75(NTR); p75NTR; TNFRSF16
Database LinkNP_002498
FunctionThe tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases (reviewed in 1). Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family (2). Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination (reviewed in 3). Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4 (4). NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins (5). Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR (6).
Related Pathway
Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of (A) 25 ng, (B) 50 ng, and (C) 100 ng of purified recombinant NGFR with NGFR antibody at 1 ug/mL.
IF Image
Immunocytochemistry of NGFR in A20 cells with NGFR antibody at 10 ug/mL.

 

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