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Home Antibody All anti-NFATC2 antibodies

Anti-NFATC2 Antibody EPR2973

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307580
  • Rabbit monoclonal antibody against NFAT1 (clone EPR2973 )
100ul 325 In Stock
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WB(1)
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Also for NFATC2 (NM_001136021)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human NFAT1 was used as an immunogen.
Clone NameEPR2973 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000 - 5,000,
Predicted MW Explanation 100 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (NFATC2), transcript variant 3
Alternative NameNFAT1; NFATP
Database LinkNP_001129493
Entrez Gene 4773 Human
FunctionNuclear factor of activated T-cells, cytoplasmic 2 (NFAT1) belongs to the NFAT family of transcription factors that are expressed in most immune cell types, and play a central role in the transcription of cytokine genes, such as IL-2, IL-4, IL-5, IL-13, IFN-gamma, TNF-alpha, and GM-CSF. The activity NFAT proteins are regulated by the calcium/calmodulin-dependent phosphatase calcineurin, a target for inhibition by CsA and FK506 (1). NFAT1 is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the NFAT transcription complex. This complex plays a central role in inducing gene transcription during the immune response (2).
Related PathwayTranscription FactorsDruggable Genome MAPK signaling pathwayWnt signaling pathwayAxon guidanceVEGF signaling pathwayNatural killer cell mediated cytotoxicityT cell receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - NFAT1 antibody [EPR2973]; All lanes : Anti-NFAT1 antibody [EPR2973] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Ramos cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 100 kDa.Observed band size : 135 kDa .

 

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