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Home Antibody All anti-NEUROG2 antibodies

Anti-NEUROG2 Antibody EPR4177

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307052 Rabbit monoclonal antibody against Neurogenin-2(clone EPR4177) 100ul $325 In Stock
LC411396 NEUROG2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Neurogenin-2 was used as an immunogen.
Clone NameEPR4177 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsICC/IF: 1:100 - 1:250; WB: 1:1000 - 1:10000
Predicted MW Explanation 29 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens neurogenin 2 (NEUROG2)
Alternative NameAtoh4; bHLHa8; Math4A; ngn-2; NGN2
Database LinkNP_076924
Entrez Gene 63973 Human
Entrez Gene 11924 Mouse
Entrez Gene 295475 Rat
FunctionNeurogenin-2 (Ngn-2) is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factors that play an important role in neurogenesis from migratory neural crest cells (1). In particular, it is critical for the differentiation and survival of midbrain dopaminergic neurons (2). Neurogenin-2, in collaboration with extrinsic signal retinoic acid (RA), triggers transcriptionally active chromatin in spinal motor neurons during development (3). Neurogenin-2 is bound by Retinoic acid receptor (RAR), and RAR is thereby recruited to motor neuron genes targeted by Neurogenin-2 (3). RA then facilitates the recruitment of a histone acetyltransferase CBP to the Neurogenin-2/RAR-complex, markedly inducing histone H3/H4-acetylation (3).
Related PathwayTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Neurogenin 2 antibody [EPR4177]; All lanes : Anti-Neurogenin 2 antibody [EPR4177] at 1/1000 dilution.Lane 1 : SH-SY5Y cell lysate.Lane 2 : HepG2 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 29 kDa.
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Immunocytochemistry/ Immunofluorescence - Neurogenin 2 antibody [EPR4177]; Immunofluorescent staining of Neurogenin 2 in SH-SY-5Y cells using TA307052 at 1/100 dilution.
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