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Home Antibody All anti-NEUROG2 antibodies

Anti-NEUROG2 Antibody EPR4178

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307051
  • Rabbit monoclonal antibody against Neurogenin-2(clone EPR4178)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC411396) , 20ug
100ul $325 3-7 Days
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WB(1)
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Also for NEUROG2 (NM_024019)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus in human Neurogenin-2 was used as an immunogen.
Clone NameEPR4178 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens neurogenin 2 (NEUROG2)
Alternative NameAtoh4; bHLHa8; Math4A; ngn-2; NGN2
Database LinkNP_076924
FunctionNeurogenin-2 (Ngn-2) is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factors that play an important role in neurogenesis from migratory neural crest cells (1). In particular, it is critical for the differentiation and survival of midbrain dopaminergic neurons (2). Neurogenin-2, in collaboration with extrinsic signal retinoic acid (RA), triggers transcriptionally active chromatin in spinal motor neurons during development (3). Neurogenin-2 is bound by Retinoic acid receptor (RAR), and RAR is thereby recruited to motor neuron genes targeted by Neurogenin-2 (3). RA then facilitates the recruitment of a histone acetyltransferase CBP to the Neurogenin-2/RAR-complex, markedly inducing histone H3/H4-acetylation (3).
Related Pathway

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WB Image
Western blot - Neurogenin 2 antibody [EPR4178]; All lanes : Anti-Neurogenin 2 antibody [EPR4178] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : SH-SY5Y cell lysate.Lane 3 : U87-MG cell lysate.Lane 4 : HepG2 cell lysate.Lane 5 : Human fetal liver lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 29 kDa.

 

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