Home Antibody All anti-NEDD4L antibodies
Anti-NEDD4L Antibody EPR8461
Also for NEDD4L (NM_001144964)
|A synthetic peptide corresponding to residues near the C-terminus of human NEDD4L was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:50000; IP: 1:10 - 1:100
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (NEDD4L), transcript variant b|
|hNEDD4-2; NEDD4-2; NEDD4.2; RSP5|
Entrez Gene 23327 Human
Entrez Gene 83814 Mouse
Entrez Gene 291553 Rat
|NEDD4L is a member of the NEDD4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. NEDD4L mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this protein may be associated with essential hypertension (1). |
|Druggable Genome Ubiquitin mediated proteolysisEndocytosis|
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Western blot - Anti-NEDD4-2 antibody [EPR8461]; All lanes : Anti-NEDD4-2 [EPR8461] antibody at 1/10000 dilution.Lane 1 : K562 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 112 kDa.