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Home Antibody All anti-NDP antibodies

Anti-NDP Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306758 Rabbit Polyclonal Norrin Antibody 100ug $325 3-7 Days
LC424827 NDP HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenNorrin antibody was raised against an 18 amino acid peptide from near the amino terminus of human Norrin.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 2 ug/ml, ICC: 5 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Norrie disease (pseudoglioma) (NDP)
Alternative NameEVR2; FEVR; ND
Database LinkNP_000257
Entrez Gene 4693 Human
FunctionNorrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/b-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina; transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/b-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.
Related PathwaySecreted ProteinDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Norrin in Jurkat cell lysate with Norrin antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry of Norrin in Jurkat cells with Norrin antibody at 5 ug/mL.


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