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Anti-NDEL1 Antibody

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IF(1)

OriGene Data

Immunogen	Nudel antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Nudel.
Clone Name		Isotype	IgG
Species Reactivity	Human, Mouse	Concentration	1ug/ul
Guaranteed Application *	WB, IF	Suggested Dilutions	ELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml, IF: 10 ug/ml
Buffer	PBS containing 0.02% sodium azide.
Purification	Affinity chromatography purified via peptide column (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens nudE nuclear distribution E homolog (A. nidulans)-like 1 (NDEL1), transcript variant 1
Alternative Name	EOPA; MITAP1; NUDEL
Database Link	NP_001020750
Function	Nudel was initially discovered as a protein homologous to Aspergillus NUDE and that associated with Lis1 and polyprotein complex cytoplasmic dynein, both of which have been linked to neuronal development and migration (1,2). It was later shown to be a substrate of cdk5, a kinase known to be critical during neuronal migration; phosphorylation of Nudel by cdk5 affects its localization in neurons and affects neuritic morphology (1,3). It is thought that together with Lis1, Nudel regulates cytoplasmic dynein, a large polyprotein complex, in neuronal migration and mitosis through direct interactions (4). Similar interactions are thought to also play a role in membrane traffic in other cells as disruption of Nudel expression through RNA interference perturbed normal endomembrane flux and resulted in the fragmentation of the Golgi apparatus (3).
Related Pathway	Cell cycle

Related Lysate from OriGene • Transient overexpression lysate of nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (NDEL1), transcript variant 1 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • NDEL1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • NDEL1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Ndel1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • NDEL1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Ndel1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (NDEL1), transcript variant 1 as transfection-ready DNA • Lenti ORF clone of Human nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (NDEL1), transcript variant 1 , Myc-DDK-tagged • Lenti ORF clone of Human nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (NDEL1), transcript variant 1, mGFP tagged • GFP-tagged ORF clone of Homo sapiens nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (NDEL1), transcript variant 1 as transfection-ready DNA Related cDNA Clones • Homo sapiens nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (NDEL1), transcript variant 1 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)