SRC-3 is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. It has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. SRC-3 is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. In addition, a polymorphic repeat region is found in the C-terminus of the protein (1).
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