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Home Antibody All anti-Mapk8ip1 antibodies

Anti-Mapk8ip1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA318944 Rabbit polyclonal anti-JIP-1 antibody 100ug $325 3-7 Days
LC417296 MAPK8IP1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for Mapk8ip1 (NM_005456)
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OriGene Data

ImmunogenSynthetic peptide from mouse JIP1
Clone Name IsotypeRabbit IgG
Species ReactivityHuman, mouse, rat Concentration0.2 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.5-4ug/ml
Buffer100µg (0.2mg/ml) protein A purified rabbit anti-JIP1 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5% BSA, 30% glycerol, and 0.01% thimerosal.
Purification Affinity purified

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1)
Alternative NameIB1; JIP-1; JIP1; PRKM8IP
Database LinkNP_005447
Entrez Gene 9479 Human
Entrez Gene 19099 Mouse
Entrez Gene 116457 Rat
FunctionJIP1 (JNK-interacting protein-1) is a cytoplasmic protein that possesses an N-terminal JNK-binding domain and a C-terminal SRC homology 3 (SH3) domain. JIP1 selectively bind to JNK, but not to the ERK or p38 MAP kinases. In addition to JNK, JIP1 binds to specific proteins of JNK pathways, including MKK7, MLK3, and DLK, all at separate binding sites. JIP1 has been identified in brain and kidney tissues, whereas JIP2a, JIP2b, and JIP3 are specifically expressed in the brain. Overexpression of JIP1 causes cytoplamic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathways, indicating that JIP1 acts as a cytoplasmic anchor for JNK.
Related PathwayDruggable Genome MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of JIP-1 in Jurkat cell lysate (Lane 1), mouse intestine (Lane 2) and rat kidney (Lane 3) tissue lysates.


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