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Anti-MYLK Antibody EP1458Y
Also for MYLK (NM_053031)
|A synthetic peptide corresponding to residues near the C-terminal of human MLCK protein was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:5000 -10,000; IHC: 1:100 - 250; ICC: 1:100 - 250; FC: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens myosin light chain kinase (MYLK), transcript variant 7|
|AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK1; smMLCK|
Entrez Gene 4638 Human
Entrez Gene 107589 Mouse
Entrez Gene 288057 Rat
|This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq]. |
|Protein KinaseDruggable Genome Calcium signaling pathwayVascular smooth muscle contractionFocal adhesionRegulation of actin cytoskeleton|
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Myosin light chain kinase antibody [EP1458Y]; Immunohistochemical analysis of paraffin embedded human smooth muscle, using TA303608, at 1/100 dilution.
Immunocytochemistry/ Immunofluorescence - Myosin light chain kinase antibody [EP1458Y]; Immunofluorescent staining of SH-SY5Y cells, using TA303608, at 1/50 dilution.