Anti-MYC Antibody,

Also for MYC (NM_002467)

OriGene Data

Immunogen	This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S373 of human MYC.
Clone Name		Isotype	Rabbit Ig
Species Reactivity	Human	Concentration	0.25 mg/ml
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:50~100; ELISA: 1: 1,000;
Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens v-myc myelocytomatosis viral oncogene homolog (avian) (MYC)
Alternative Name	bHLHe39; c-Myc; MRTL
Database Link	NP_002458
Function	MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of the gene encoding MYC have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Related Pathway	Apoptosis Cell cycle EGFR1 Signaling Pathway Jak-STAT signaling pathway MAPK signaling pathway TGF Beta Signaling Pathway Wnt Signaling Pathway

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WB Image

Western blot analysis of MYC (arrow) using rabbit polyclonal MYC Antibody (S373) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MYC gene (Lane 2) (Origene Technologies).

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

HRP
Biotin
PE
FITC
DyLight® 488
DyLight® 550
DyLight® 594
DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-MYC Antibody

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data