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Anti-MYB Antibody EPR718(2)
|A synthetic peptide corresponding to residues in human c-Myb was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens v-myb avian myeloblastosis viral oncogene homolog (MYB), transcript variant 2|
|c-myb; c-myb_CDS; Cmyb; efg|
|The c-Myb proto-oncogene is a protein involved in growth regulation and differentiation in many different cell types, but it is predominantly expressed in immature hematopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs, and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells (2). Therefore, disrupting c-myb function might be an effective therapeutic strategy for controlling leukemic cell growth (3). c-Myb binds to promoter sequences, such as c-Myc or Bcl-2, which are expressed in cutaneous T-cell lymphoma.|
Wnt Signaling Pathway
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Western blot - c-Myb antibody [EPR718(2)]; All lanes : Anti-c-Myb antibody [EPR718(2)] at 1/1000 dilution.Lane 1 : Jurkat cell lysates.Lane 2 : MOLT4 cell lysates.Lysates/proteins at 10 µg per lane.Predicted band size : 72 kDa.