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Anti-MYB Antibody EP769Y
|A synthetic peptide corresponding to residues near the N-terminus of human c-myb was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:5000; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250; IP: 1:50; ChIP: Use at an assay dependent dilution
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt.
|Homo sapiens v-myb avian myeloblastosis viral oncogene homolog (MYB), transcript variant 2|
|c-myb; c-myb_CDS; Cmyb; efg|
|The c-Myb proto-oncogene is a 75 kDa protein involved in growth regulation and differentiation in many different cell types but it is predominantly expressed in immature hemopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells (2). Disrupting c-myb function might, therefore, prove an effective therapeutic strategy for controlling leukemic cell growth (3). c-Myb binds to promoter sequences of genes such as c-Myc or Bcl-2 that are expressed in cutaneous T-cell lymphoma. |
Wnt Signaling Pathway
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Western blot - v-Myb / c-Myb antibody [EP769Y]; Anti-v-Myb + c-Myb antibody [EP769Y] - ChIP Grade at 1/10000 dilution + Ramos membrane.Predicted band size : 72 kDa.Observed band size : 72,75 kDa .
Immunohistochemistry (Paraffin-embedded sections) - v-Myb / c-Myb antibody [EP769Y]; Ab45150 staining human v-Myb / c-Myb in human cervical carcinoma by immunohistochemistry using paraffin embedded tissue.