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Home Antibody All anti-MUC16 antibodies

Anti-MUC16 Antibody EPR1020(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307044
  • Rabbit monoclonal antibody against CA 125(clone EPR1020(2))
100ul 325 3-7 Days
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WB(1)
IHC(10)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CA 125 was used as an immunogen.
Clone NameEPR1020(2) IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens mucin 16, cell surface associated (MUC16)
Alternative NameCA125
Database LinkNP_078966
Entrez Gene 94025 Human
FunctionCarcinoma antigen 125 (CA 125) is a high molecular weight tumor antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer (1). It is a heavily glycosylated mucin expressed on the surface of ovarian tumor cells and on human MUC16, a cell surface bound mucin that is also shed by proteolytic cleavage (2, 3). Furthermore, MUC16 is a potent inhibitor of natural killer cell mediated anti-tumor cytotoxic responses (3). Binding of CA125 to membrane-bound mesothelin mediates heterotypic cell adhesion, which may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CA 125 antibody [EPR1020(2)]; Anti-CA 125 antibody [EPR1020(2)] at 1/1000 dilution + Human uterus cell lysate at 10 ug.Predicted band size : 2353 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CA 125 antibody [EPR1020(2)]; TA307044 at 1/100 dilution staining CA 125 in Human serous carcinoma by Immunohistochemistry, Paraffin-embedded tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CA 125 antibody [EPR1020(2)]; TA307044 at 1/100 dilution staining CA 125 in Human mucinous carcinoma by Immunohistochemistry, Paraffin-embedded tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CA 125 antibody [EPR1020(2)](TA307044); TA307044 showing positive staining in Serous ovarian carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CA 125 antibody [EPR1020(2)](TA307044); TA307044 showing positive staining in Normal uterus tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CA 125 antibody [EPR1020(2)](TA307044); TA307044 showing negative staining in Cervical carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CA 125 antibody [EPR1020(2)](TA307044); TA307044 showing negative staining in Colonic adenocarcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CA 125 antibody [EPR1020(2)](TA307044); TA307044 showing negative staining in Normal kidney tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CA 125 antibody [EPR1020(2)](TA307044); TA307044 showing negative staining in Normal colon tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CA 125 antibody [EPR1020(2)](TA307044); TA307044 showing negative staining in Normal breast tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-CA 125 antibody [EPR1020(2)](TA307044); TA307044 showing negative staining in Normal brain tissue.

 

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