Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) (MTOR)
Synonyms:
FRAP; FRAP1; FRAP2; RAFT1; RAPT1
Immunogen
A phospho specific peptide corresponding to residues surrounding serine 2448 of human mTOR/FRAP was used as an immunogen. This antibody only detects mTOR/FRAP phosphorylated at serine 2448.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
The mammalian target of rapamycin (mTOR) is a major effector of cell growth and proliferation via the regulation of protein synthesis. mTOR is composed of an N-terminal half of 20 tandem HEAT repeats that are implicated in protein-protein interactions and a C-terminal half that includes a FAT domain, a FBR domain, a kinase domain, a NDR domain and a FATC domain. The FATC domain is essential to mTOR activity, and the deletion of a single amino acid from this domain abrogates this activity. mTOR can be auto-phosphorylated via its intrinsic serine/threonine kinase activity. mTOR regulates protein synthesis through the phosphorylation and inactivation of the mRNA translation repressor, 4E-BP1, and also through the phosphorylation and activation of S6 kinase. RAPTOR (regulatory associated protein of TOR) is a positive regulator of TOR. Moreover, other known mediators of mTOR include PI3-K and ATK from the insulin pathway.
Related Pathway
Senescence and Autophagy
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