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Home Antibody All anti-MTA2 antibodies

Anti-MTA2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306072
  • Rabbit Polyclonal PID Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenPID antibody was raised against a synthetic peptide corresponding to amino acids 652 to 668 of human PID (6), which differ from the mouse sequence by one amino acid (7) .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens metastasis associated 1 family, member 2 (MTA2)
Alternative NameMTA1L1; PID
Database LinkNP_004730
Entrez Gene 9219 Human
Entrez Gene 23942 Mouse
Entrez Gene 361724 Rat
FunctionThe p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex (6-8). PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis (6). PID/MTA2 is ubiquitously expressed in human tissues (8).
Related PathwayTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PID expression in HeLa whole cell lysates in the absence (A) or presence (B) of blocking peptide with PID antibody at 1 ug /ml.
IF Image
Immunocytochemistry staining of HeLa using PID antibody at 10 ug/mL.

 

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