Home Antibody All anti-MTA2 antibodies
Also for MTA2 (NM_004739)
|PID antibody was raised against a synthetic peptide corresponding to amino acids 652 to 668 of human PID (6), which differ from the mouse sequence by one amino acid (7) .|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified
|Homo sapiens metastasis associated 1 family, member 2 (MTA2)|
Entrez Gene 9219 Human
Entrez Gene 23942 Mouse
Entrez Gene 361724 Rat
|The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex (6-8). PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis (6). PID/MTA2 is ubiquitously expressed in human tissues (8).|
|Transcription FactorsDruggable Genome |
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Western blot analysis of PID expression in HeLa whole cell lysates in the absence (A) or presence (B) of blocking peptide with PID antibody at 1 ug /ml.
Immunocytochemistry staining of HeLa using PID antibody at 10 ug/mL.