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Anti-MSH2 Antibody EPR3943


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307731 Rabbit monoclonal antibody against MSH2(clone EPR3943) 100ul $325 In Stock
LC424843 MSH2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the N-terminus in human MSH2 was used as an immunogen.
Clone NameEPR3943 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC/IF or IP.

Reference Data

Target NameHomo sapiens mutS homolog 2 (MSH2), transcript variant 1
Alternative NameCOCA1; FCC1; HNPCC; HNPCC1; LCFS2
Database LinkNP_000242
Entrez Gene 4436 Human
FunctionMutS homologue 2 (MSH2) is a DNA mismatch repair protein in the MutS family (1). MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3) that bind to DNA mismatches thereby initiating DNA repair. (2). MutS alpha bends the DNA helix and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA (2). MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long (2). Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6 (3, 4). MutS alpha may also play a role in DNA homologous recombination repair (2).
Related PathwayStem cell - PluripotencyDruggable Genome Mismatch repairPathways in cancerColorectal cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - MSH2 antibody [EPR3943]; All lanes : Anti-MSH2 antibody [EPR3943] at 1/1000 dilution.Lane 1 : A375 cell lysate.Lane 2 : A431 cell lysate.Lane 3 : SW480 cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit antibody at 1/2000 dilution.Predicted band size : 105 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MSH2 antibody [EPR3943]; TA307731, at a 1/100 dilution, staining MSH2 in paraffin embedded Human colonic adenocarcinoma by Immunohistochemistry. Detection utilised HRP conjugated anti-rabbit antibody.
Immunocytochemistry/ Immunofluorescence - Anti-MSH2 antibody [EPR3943]; TA307731 (1/500) staining MSH2 in assynchronous Hela cells (green). Cells were fixed in formaldehyde, permeabilised with 0.5% Triton X-100 (in PBS) and counterstained with DAPI in order to highlight the nuceleus (red).
Immunocytochemistry/ Immunofluorescence - MSH2 antibody [EPR3943]; TA307731, at a 1/100 dilution, staining MSH2 in HeLa cells by Immunofluorescence.


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