Home Antibody All anti-MRE11A antibodies
Also for MRE11A (NM_005590)
|MRE11 antibody was raised against a 14 amino acid peptide from near the amino terminus human MRE11.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A), transcript variant 2|
|ATLD; HNGS1; MRE11; MRE11B|
Entrez Gene 4361 Human
Entrez Gene 17535 Mouse
Entrez Gene 64046 Rat
|MRE11 is involved in the repair of DNA double strand breaks as part of a complex that includes the Rad50 and NBS1 protein and is thought to act in the same pathway as the A-T mutated (ATM) protein. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for non-homologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Mutations in this protein result in a novel ataxia telangiectasia-like disorder (ATLD). Unlike the ATM protein, MRE11 is necessary proper mammalian development.|
|Stem cell - PluripotencyDruggable Genome Homologous recombinationNon-homologous end-joining|
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Western blot analysis of MRE11 in rat lung tissue lysate with MRE11 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of MRE11 in rat lung tissue with MRE11 antibody at 5 ug/mL.
Immunofluorescence of MRE11 in rat lung tissue with MRE11 antibody at 20 ug/mL.