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Home Antibody All anti-MMP2 antibodies

Anti-MMP2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308925
  • Rabbit Polyclonal antibody to MMP2 (matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase))
100ul 325 3-7 Days
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WB(2)
IHC(1)
IF(1)
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Also for MMP2 (NM_001127891)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 193 and 575 of MMP2 (Uniprot ID#P08253)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Xenopus laevis, Bovine) Concentration0.55mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 74kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Xenopus laevis (81%), Bovine (94%)

Reference Data

Target NameHomo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (MMP2), transcript variant 2
Alternative NameCLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1
Database LinkNP_001121363
Entrez Gene 4313 Human
Entrez Gene 17390 Mouse
FunctionProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Related PathwayProteaseDruggable Genome Leukocyte transendothelial migrationGnRH signaling pathwayPathways in cancerBladder cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (50 ug of whole cell lysate). A: Mouse brain. 7.5% SDS PAGE. TA308925 diluted at 1:1000.
WB Image
MMP2 antibody detects MMP2 protein by western blot analysis. Various whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with MMP2 antibody (TA308925) diluted by 1:3000.
IHC Image
Immunohistochemical analysis of paraffin-embedded U251 xenograft, using MMP2(TA308925) antibody at 1:500 dilution.
IF Image
Immunofluorescence analysis of methanol-fixed HeLa, using MMP2(TA308925) antibody at 1:200 dilution.

 

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