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Anti-MKNK1 PHOSPHO Antibody EPR2370


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Mnk1 Phospho (pT385)(clone EPR2370) (Phospho-Specific)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Mnk1 Phospho (pT385) was used as an immunogen.
Clone NameEPR2370 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens MAP kinase interacting serine/threonine kinase 1 (MKNK1), transcript variant 2
Alternative NameMNK1
Database LinkNP_945324
Entrez Gene 8569 Human
FunctionMnk1 (MAPK-interacting kinase 1) is a MAPK-regulated kinase in the CAMK Serine/Threonine protein kinase family that phosphorylates the initiation factor eIF4E (1, 2). Mnk1 is phosphorylated in response to type I IFNs in an Erk/MAPK-dependent manner (1). Furthermore, it is activated by the p38 kinases and kinases in the Erk pathway (2). Phosphorylation of Threonine 385 activates this kinase (2). Mnk1 may also play a role in the response to environmental stress and cytokines (2).
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayInsulin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - MNK1 (phospho T385) antibody [EPR2370]; All lanes : Anti-MNK1 (phospho T385) antibody [EPR2370] at 1/1000 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate, treated with Calyculin A.Lysates/proteins at 10 ug per lane.Predicted band size : 51 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MNK1 (phospho T385) antibody [EPR2370]; Immunohistochemical analysis of MNK1 (phospho T385) expression in paraffin-embedded Human colon tissue using TA307346 at 1/250 dilution.


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