OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-MDM4 antibodies

Anti-MDM4 TRUEMAB Antibody Clone 4D2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA505727
  • MDM4 (MDMX) mouse monoclonal antibody, Clone 4D2
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400856) , 20ug Explanation
100ul 325 In Stock
CF505727
  • Carrier-free (BSA/glycerol-free) MDM4 mouse monoclonal antibody,clone 4D2
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
This antibody qualifies for Season of Giving promotion: Earn $50 Amazon gift card (use promo code SPQ12081) or donation to Cancer.org (promo code SPQ12082) with $600 purchase of UltraMAB or TrueMAB. Click for details
Add to Shopping Cart
WB(1)
IF(1)

OriGene Data

ImmunogenFull length human recombinant protein of human MDM4(NP_002384) produced in HEK293T cell.
Clone NameClone 4D2 IsotypeIgG2b
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IF Suggested Dilutions WB 1:4000, IF 1:100,
Predicted MW Explanation 54.7 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens MDM4, p53 regulator (MDM4), transcript variant 1
Alternative NameHDMX; MDMX; MRP1
Database LinkNP_002384
Entrez Gene 4194 Human
FunctionThis gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].
Related PathwayTranscription FactorsDruggable Genome p53 signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MDM4 (RC209620, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MDM4.
IF Image
Immunofluorescent staining of HeLa cells using anti-MDM4 mouse monoclonal antibody (TA505727).

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title