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Home Antibody All anti-MCM3 antibodies

Anti-MCM3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308761
  • Rabbit Polyclonal antibody to MCM3 (minichromosome maintenance complex component 3)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419355) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for MCM3 (NM_002388)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 42 and 302 of MCM3 (Uniprot ID#P25205)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Rhesus Monkey) Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:5000-1:20000
Predicted MW Explanation 91kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Rhesus Monkey (100%)

Reference Data

Target NameHomo sapiens minichromosome maintenance complex component 3 (MCM3), transcript variant 1
Alternative NameHCC5; P1-MCM3; P1.h; RLFB
Database LinkNP_002379
Entrez Gene 4172 Human
Entrez Gene 708320 Monkey
FunctionThe protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [provided by RefSeq]
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome DNA replicationCell cycle

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). A: Hep G2 . 7.5% SDS PAGE. TA308761 diluted at 1:10000.
IHC Image
Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using MCM3(TA308761) antibody at 1:500 dilution.
IF Image
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using MCM3(TA308761) antibody at 1:500 dilution.

 

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