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Home Antibody All anti-MC4R antibodies

Anti-MC4R Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306791 Rabbit Polyclonal MC4R Antibody 100ug $325 In Stock
LC401792 MC4R HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenMC4R antibody was raised against a 19 amino acid peptide near the amino terminus of human MC4R.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens melanocortin 4 receptor (MC4R)
Alternative NameMGC126851; MGC138197
Database LinkNP_005903
Entrez Gene 4160 Human
Entrez Gene 17202 Mouse
Entrez Gene 25635 Rat
FunctionThe melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.
Related PathwayGPCRTransmembraneDruggable Genome Neuroactive ligand-receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

IHC Image
Immunohistochemistry of MC4R in human brain tissue with MC4R antibody at 2.5 ug/ml.

IF Image
Immunofluorescence of MC4R in Human Brain cells with MC4R antibody at 20 ug/mL.


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