Home Antibody All anti-MC4R antibodies
Also for MC4R (NM_005912)
|MC4R antibody was raised against a 19 amino acid peptide near the amino terminus of human MC4R.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens melanocortin 4 receptor (MC4R)|
|The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.|
Signaling by GPCR
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Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of MC4R in human brain tissue with MC4R antibody at 2.5 ug/ml.