OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-MC4R antibodies

Anti-MC4R Antibody

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306791
  • Rabbit Polyclonal MC4R Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401792) , 20ug
100ug 325 In Stock
Add to Shopping Cart
WB(1)
IHC(1)
spacer
Also for MC4R (NM_005912)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenMC4R antibody was raised against a 19 amino acid peptide near the amino terminus of human MC4R.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens melanocortin 4 receptor (MC4R)
Alternative NameMGC126851; MGC138197
Database LinkNP_005903
FunctionThe melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.
Related Pathway
Signaling by GPCR

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
IHC Image
Immunohistochemistry of MC4R in human brain tissue with MC4R antibody at 2.5 ug/ml.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title