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Home Antibody All anti-MC1R antibodies

Anti-MC1R Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308794
  • Rabbit polyclonal antibody to MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400853) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(2)

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 253 and 317 of MC1 Receptor (Uniprot ID#Q01726)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Chicken, Chimpanzee) Concentration0.63mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 35kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Chicken (80%), Chimpanzee (100%)

Reference Data

Target NameHomo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R)
Alternative NameCMM5; MSH-R; SHEP2
Database LinkNP_002377
Entrez Gene 4157 Human
FunctionThis intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq]
Related PathwayGPCRTransmembraneDruggable Genome Neuroactive ligand-receptor interactionMelanogenesis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). A: Molt-4 . 10% SDS PAGE. TA308794 diluted at 1:1000.
IHC Image
MC1 Receptor antibody [C2C3], C-term detects MC1R protein at membrane on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. MC1 Receptor antibody [C2C3], C-term (TA308794) dilution: 1:500.
IHC Image
MC1 Receptor antibody [C2C3], C-term detects MC1R protein at cytosol and membrane on colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded colon carcinoma. MC1 Receptor antibody [C2C3], C-term (TA308794) dilution: 1:500.

 

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