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Home Antibody All anti-MC1R antibodies

Anti-MC1R Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308794
  • Rabbit polyclonal antibody to MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor))
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400853) , 20ug
100ul $325 Next Day
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OriGene Data

ImmunogenSynthetic peptide contain a sequence corresponding to a region within amino acids 253 and 317 of Human MC1R
Clone Name IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB:1:500-1:3000;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R)
Alternative NameCMM5; MSH-R; SHEP2
Database LinkNP_002377
FunctionThis intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq]
Related Pathway
Melanogenesis
Signaling by GPCR

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WB Image
A: Molt-4 (anti-MC1R antibody diluted at 1:1000)

 

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