OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-MBD1 antibodies

Anti-MBD1 Antibody EPR3564

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307448
  • Rabbit monoclonal antibody against MBD1(clone EPR3564)
100ul 325 3-7 Days
Add to Shopping Cart
WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MBD1 was used as an immunogen
Clone NameEPR3564 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:500 - 1:1000; IP: 1:20; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens methyl-CpG binding domain protein 1 (MBD1), transcript variant 4
Alternative NameCXXC3; PCM1; RFT
Database LinkNP_002375
Entrez Gene 4152 Human
FunctionMethyl-CpG-binding domain protein 1 (MBD1) is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (1). Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. It is also believed to form a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (2).
Related PathwayTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - MBD1 antibody [EPR3564]; All lanes : Anti-MBD1 antibody [EPR3564] at 1/500 dilution.Lane 1 : HeLa cell lysate.Lane 2 : A431 cell lysate.Lane 3 : 293T cell lysate.Lane 4 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 67 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MBD1 antibody [EPR3564]; TA307448, at 1/100 dilution, staining MBD1 in paraffin-embedded Human tonsil tissue by Immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - MBD1 antibody [EPR3564]; TA307448, at 1/100 dilution, staining MBD1 in MCF7 cells by Immunofluorescence.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title