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Home Antibody All anti-MAVS antibodies

Anti-MAVS Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306399 Rabbit Polyclonal VISA Antibody 100ug $325 In Stock
LC412370 MAVS HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenVISA antibody was raised against a 13 amino acid peptide from near the amino terminus of human VISA.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens mitochondrial antiviral signaling protein (MAVS), transcript variant 1
Alternative NameCARDIF; IPS-1; IPS1; VISA
Database LinkNP_065797
Entrez Gene 57506 Human
Entrez Gene 228607 Mouse
Entrez Gene 311430 Rat
FunctionTwo distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
Related PathwayTransmembrane RIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of VISA in A20 cell lysate with VISA antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry of VISA in human brain tissue with VISA antibody at 5 ug/ml.


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