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Home Antibody All anti-MAPT antibodies

Anti-MAPT PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA323804
  • Anti-Mapt (phospho-Ser416) Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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WB(1)

OriGene Data

ImmunogenPeptide sequence around phosphorylation site of serine 416 (T-G-S(p)-I-D) derived from Rat Mapt.
Clone Name IsotypeIgG
Species ReactivityRat Concentration1mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500-1000
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameRattus norvegicus microtubule-associated protein tau (Mapt)
Alternative NameMtapt; pTau; RNPTAU
Database LinkNP_058908
FunctionTau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3).
Related Pathway

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WB Image
Predicted band size: 48; 62; 78 kDa . Positive control: Rat brain, rat hippocampus and mouse brain tissue lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1,2,3: Rat brain, rat hippocampus and mouse brain lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

 

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