Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer’s disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and phosphorylation sites have been implicated in the loss of Tau's association with the membrane cortex during AD progression (3). Protein kinase C and calmodulin-dependent protein kinase II (Cam kinase II) phosphorylate Tau on Ser 324 and Ser 416, respectively (4).
MAPK signaling pathway
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