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Anti-MAPT PHOSPHO Antibody EPR2457(2)
Also for MAPT (NM_016841)
|A phospho specific peptide corresponding to residues surrounding Serine 324 of human Tau was used as an immunogen. This antibody only detects Tau phosphorylated at Serine 324.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:10000 - 1:50000; IP: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 4|
|DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU|
|Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer’s disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and phosphorylation sites have been implicated in the loss of Tau's association with the membrane cortex during AD progression (3). Protein kinase C and calmodulin-dependent protein kinase II (Cam kinase II) phosphorylate Tau on Ser 324 and Ser 416, respectively (4).|
MAPK signaling pathway
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Western blot - Tau (phospho S324) antibody [EPR2457(2)]; All lanes : Anti-Tau (phospho S324) antibody [EPR2457(2)] at 1/10000 dilution.Lane 1 : SH-SY5Y cell lysate untreated.Lane 2 : SH-SY5Y cell lysate treated with Okadaic acid and Calyculin A.Lysates/proteins at 10 µg per lane.Predicted band size : 79 kDa.
Immunocytochemistry/ Immunofluorescence - Tau (phospho S324) antibody [EPR2457(2)]; Immunofluorescent staining of Tau in SH-SY5Y cells using TA307802 at 1/100.