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Home Antibody All anti-MAPT antibodies

Anti-MAPT PHOSPHO Antibody EPR2457(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307802
  • Rabbit monoclonal antibody against Tau Phospho (pS324)(clone EPR2457(2)) (Phospho-Specific)
100ul 325 In Stock
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WB(1)
IF(1)
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Also for MAPT (NM_016841)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 324 of human Tau was used as an immunogen. This antibody only detects Tau phosphorylated at Serine 324.
Clone NameEPR2457(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 79 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens microtubule-associated protein tau (MAPT), transcript variant 4
Alternative NameDDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU
Database LinkNP_058525
Entrez Gene 4137 Human
Entrez Gene 17762 Mouse
Entrez Gene 29477 Rat
FunctionTau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer’s disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and phosphorylation sites have been implicated in the loss of Tau's association with the membrane cortex during AD progression (3). Protein kinase C and calmodulin-dependent protein kinase II (Cam kinase II) phosphorylate Tau on Ser 324 and Ser 416, respectively (4).
Related PathwayDruggable Genome MAPK signaling pathwayAlzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Tau (phospho S324) antibody [EPR2457(2)]; All lanes : Anti-Tau (phospho S324) antibody [EPR2457(2)] at 1/10000 dilution.Lane 1 : SH-SY5Y cell lysate untreated.Lane 2 : SH-SY5Y cell lysate treated with Okadaic acid and Calyculin A.Lysates/proteins at 10 ug per lane.Predicted band size : 79 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - Tau (phospho S324) antibody [EPR2457(2)]; Immunofluorescent staining of Tau in SH-SY5Y cells using TA307802 at 1/100.

 

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