Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2
Synonyms:
DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU
Immunogen
A phospho specific peptide corresponding to residues surrounding Serine 324 of human Tau was used as an immunogen. This antibody only detects Tau phosphorylated at Serine 324.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer’s disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and phosphorylation sites have been implicated in the loss of Tau's association with the membrane cortex during AD progression (3). Protein kinase C and calmodulin-dependent protein kinase II (Cam kinase II) phosphorylate Tau on Ser 324 and Ser 416, respectively (4).
Related Pathway
MAPK signaling pathway
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