Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2
Synonyms:
DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU
Immunogen
A phospho specific peptide corresponding to residues surrounding threonine 50 of human Tau was used as an immunogen. This antibody only detects Tau phosphorylated at threonine 50.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).
Related Pathway
MAPK signaling pathway
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