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Home Antibody All anti-MAPT antibodies

Anti-MAPT PHOSPHO Antibody EPR2396(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307184
  • Rabbit monoclonal antibody against Tau Phospho (pT50)(clone EPR2396(2)) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
IHC(2)
IF(1)
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Also for MAPT (NM_016841)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding threonine 50 of human Tau was used as an immunogen. This antibody only detects Tau phosphorylated at threonine 50.
Clone NameEPR2396(2) IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; ICC/IF: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens microtubule-associated protein tau (MAPT), transcript variant 4
Alternative NameDDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU
Database LinkNP_058525
FunctionTau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).
Related Pathway
MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Tau (phospho T50) antibody [EPR2396(2)]; All lanes : Anti-Tau (phospho T50) antibody [EPR2396(2)] at 1/1000 dilution.Lane 1 : SH-SY5Y cell lysates, untreated.Lane 2 : SH-SY5Y cell lysates, treated with Okadiac acid and Calyculin A.Lysates/proteins at 10 ug per lane.Predicted band size : 79 kDa.
IHC Image
Tau (phospho T50) antibody [EPR2396(2)]; Immunohistochemical analysis of paraffin-embedded Human brain tissue using 1/250 TA307184.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Tau (phospho T50) antibody [EPR2396(2)]; Immunohistochemical analysis of paraffin-embedded Human glioma tissue using 1/250 TA307184.
IF Image
Immunocytochemistry/ Immunofluorescence - Tau (phospho T50) antibody [EPR2396(2)]; Immunofluorescent staining of SHSY5Y cells using 1/100 TA307184.

 

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