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Anti-MAPT PHOSPHO Antibody EPR2866
Also for MAPT (NM_016841)
|A phospho-specific peptide corresponding to residues surrounding serine 422 of human Tau was used as an immunogen. The antibody only detects Tau phosphorylated on serine 422.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:20000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 4|
|DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU|
|Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Serine 199/202, Threonine 231, and Serine 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Serine 396 (4).|
MAPK signaling pathway
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Western blot - Anti-Tau (phospho S422) antibody [EPR2866]; All lanes : Anti-Tau (phospho S422) antibody [EPR2866] at 1/20000 dilution.Lane 1 : SH-SY5Y cell lysates.Lane 2 : SH-SY5Y cell lysates treated with Okadiac acid and calyculin A.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 79 kDa.Observed band size : 55 kDa .