Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 2
Synonyms:
DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU
Immunogen
A phospho-specific peptide corresponding to residues surrounding serine 198 of human Tau was used as an immunogen. The antibody only detects Tau phosphorylated on serine 198.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Serine 199/202, Threonine 231, and Serine 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Serine 396 (4).
Related Pathway
MAPK signaling pathway
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