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Anti-MAPT PHOSPHO Antibody EPR2400
Also for MAPT (NM_016841)
|A phospho-specific peptide corresponding to residues surrounding serine 198 of human Tau was used as an immunogen. The antibody only detects Tau phosphorylated on serine 198.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:50000 - 1:100000; IP: 1:50; IHC-P: 1:100 - 1:250; ICC: 1:50 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt.
|Homo sapiens microtubule-associated protein tau (MAPT), transcript variant 4|
|DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU|
|Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Serine 199/202, Threonine 231, and Serine 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Serine 396 (4).|
MAPK signaling pathway
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Western blot - Anti-Tau (phospho S198) antibody [EPR2400]; All lanes : Anti-Tau (phospho S198) antibody [EPR2400] at 1/100000 dilution.Lane 1 : SH-SY5Y cell lysate.Lane 2 : SH-SY5Y cell lysate treated with AP.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 79 kDa.Observed band size : 50 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tau (phospho S198) antibody [EPR2400]; ab79540, at 1/100 dilution, staining Tau (phospho S198) in paraffin-embedded human brain tissue by Immunohistochemistry.