Home Antibody All anti-MAPK8 antibodies
Also for MAPK8 (NM_139046)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 5 and 270 of JNK1|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b1|
|JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c|
|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]|
EGFR1 Signaling Pathway
MAPK signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
Wnt Signaling Pathway
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A: Jurkat (anti-MAPK8 antibody diluted at 1:1000)
A: Mouse brain (anti-MAPK8 antibody diluted at 1:1000)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using JNK1(anti-MAPK8 antibody) antibody at 1:200 dilution.