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Anti-MAPK8 Antibody EPR140(2)
Also for MAPK8 (NM_139049)
|A synthetic peptide corresponding to residues in human JNK1 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a2|
|JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c|
|C-Jun N-terminal kinase 1 (JNK1) is a member of the mitogen-activated protein kinase (MAPK) family (1). It is activated by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, such as AP-1, and thus regulates AP-1 transcriptional activity (2). JNK1 regulates microtubule assembly in neuronal cells and microtubule-associated proteins (MAP) activity, maintaining the cytoskeletal integrity of neurons (1). In T-cells, JNK1 and its JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (2). JNK1 plays a role in obesity (3). A JNK1 deficiency results in reduced adiposity and improved insulin sensitivity (3).|
EGFR1 Signaling Pathway
MAPK signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
Wnt Signaling Pathway
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Western blot - JNK1 antibody [EPR140(2)]; All lanes : Anti-JNK1 antibody [EPR140(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : 293T cell lysate.Lane 3 : K562 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 48 kDa.