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Home Antibody All anti-MAPK8 antibodies

Anti-MAPK8 Antibody EPR140(2)

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SKU Description Amount Price Availability*  
TA307854
  • Rabbit monoclonal antibody against JNK1(clone EPR140(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC408403) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)
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Also for MAPK8 (NM_139049)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human JNK1 was used as an immunogen.
Clone NameEPR140(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 48 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a2
Alternative NameJNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
Database LinkNP_620637
Entrez Gene 5599 Human
Entrez Gene 26419 Mouse
Entrez Gene 116554 Rat
FunctionC-Jun N-terminal kinase 1 (JNK1) is a member of the mitogen-activated protein kinase (MAPK) family (1). It is activated by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, such as AP-1, and thus regulates AP-1 transcriptional activity (2). JNK1 regulates microtubule assembly in neuronal cells and microtubule-associated proteins (MAP) activity, maintaining the cytoskeletal integrity of neurons (1). In T-cells, JNK1 and its JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (2). JNK1 plays a role in obesity (3). A JNK1 deficiency results in reduced adiposity and improved insulin sensitivity (3).
Related PathwayProtein KinaseES Cell Differentiation/IPSDruggable Genome MAPK signaling pathwayErbB signaling pathwayWnt signaling pathwayFocal adhesionToll-like receptor signaling pathwayNOD-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - JNK1 antibody [EPR140(2)]; All lanes : Anti-JNK1 antibody [EPR140(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : 293T cell lysate.Lane 3 : K562 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 48 kDa.
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