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Anti-JNK1 Phospho Antibody EPR5693
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Also for JNK1 (NM_002753)
|A synthetic phospho-peptide corresponding to residues surrounding threonine 221 of human JNK3 was used as immunogen. The antibody will detect JNK1 (pT183), JNK2(pT183) and JNK3 (pT221).|
|Human, Mouse, Rat
||WB: 1:1,000 - 10,000; IHC 1:100 - 250;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens mitogen-activated protein kinase 10 (MAPK10), transcript variant 1|
|JNK3; JNK3A; p493F12; p54bSAPK; PRKM10; SAPK1b|
|C-Jun N-terminal kinases (JNK) are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group consists of three isoforms (JNK1, 2, and 3) and regulates transcription activity of the AP-1 complex, and release and regulation of cytochome c (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). Unlike other JNK isoforms, JNK3 is only expressed in the heart and nervous system. JNK3 has been implicated in stress-induced neuronal apoptosis (3).|
MAPK signaling pathway
Toll-like receptor signaling pathway
Wnt Signaling Pathway
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Western blot analysis on NIH/3T3 cell lysates using anti-Phospho-JNK1 (pT183) / JNK2 (pT183) / JNK3 (pT221) RabMAb. Cells were either (A) untreated (B) treated with Anisomycin.
Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-Phospho-JNK1 (pT183) / JNK2 (pT183) / JNK3 (pT221) RabMAb.