Home Antibody All anti-MAP3K7IP1 antibodies
Also for MAP3K7IP1 (NM_006116)
|TAB1 antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.|
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 1 ug/ml, IF: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha|
|3 -Tab1; MAP3K7IP1|
|TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7 (1), which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily (2), thus acting as an intermediate in both proliferative and innate and adaptive immune responses (3). This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals (4,5). It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1 (6).|
MAPK signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
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Western blot analysis of TAB1 in 3T3 cell lysate with TAB1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
Immunocytochemistry of TAB1 in K562 cells with TAB1 antibody at 1 ug/mL.