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Home Antibody All anti-MAP3K7IP1 antibodies

Anti-MAP3K7IP1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306187 Rabbit Polyclonal TAB1 Antibody 100ug $325 3-7 Days
LC416846 TAB1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IF(1)
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Also for MAP3K7IP1 (NM_006116)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenTAB1 antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 1 ug/ml, IF: 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1), transcript variant alpha
Alternative Name3 -Tab1; MAP3K7IP1
Database LinkNP_006107
Entrez Gene 10454 Human
Entrez Gene 66513 Mouse
FunctionTAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7 (1), which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily (2), thus acting as an intermediate in both proliferative and innate and adaptive immune responses (3). This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals (4,5). It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1 (6).
Related PathwayDruggable Genome MAPK signaling pathwayToll-like receptor signaling pathwayNOD-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of TAB1 in 3T3 cell lysate with TAB1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
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Immunocytochemistry of TAB1 in K562 cells with TAB1 antibody at 1 ug/mL.
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