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Home Antibody All anti-MAP3K5 antibodies

Anti-MAP3K5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305959
  • Rabbit Polyclonal ASK1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401794) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for MAP3K5 (NM_005923)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenASK1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human ASK1 This sequence is different from that of mouse by last two amino acids.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Alternative NameASK1; MAPKKK5; MEKK5
Database LinkNP_005914
FunctionMitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-alpha-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
Related Pathway
MAPK signaling pathway

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WB Image
Western blot analysis of ASK1 in SW1353 whole cell lysate with ASK1 antibody at 1:500 dilution.
IF Image
Immunocytochemistry of ASK1 in A431 cells with ASK1 antibody at 10 ug/mL.

 

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