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Anti-MAP2K3 PHOSPHO Antibody
Also for MAP2K3 (NM_145109)
|The antiserum was produced against synthesized phosphopeptide derived from human MKK3 around the phosphorylation site of Serine 189(V-D-SP-V-A).|
||WB: 1:500-1:3000; IHC: 1:50-1:100; ELISA: 1:5000
|Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
|Homo sapiens mitogen-activated protein kinase kinase 3 (MAP2K3), transcript variant B|
|MAPKK3; MEK3; MKK3; PRKMK3; SAPKK-2; SAPKK2|
|The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008].|
EGFR1 Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
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Western blot analysis of the extracts from MDA-MB- 435 cells treated or untreated with UV using MKK3 (Ab-189) Antibody and MKK3 (Phospho- Ser189) Antibody.The lane on the right is treated with the synthesized peptide.
Immunohistochemical analysis of paraffin- embedded breast carcinoma, using MKK3 (Phospho- Ser189) Antibody. Left: Untreated; Right: Treated with synthesized phosphopeptide.The picture on the right is treated with the synthesized peptide.