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Home Antibody All anti-MAP2K3 antibodies

Anti-MAP2K3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302122
  • Rabbit Polyclonal Antibody against MAP2K3 (S189)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403425) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for MAP2K3 (NM_145109)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S189 of human MAP2K3.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman Concentration0.25 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50~100; IHC: 1: 10~50; ELISA: 1: 1,000;
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase 3 (MAP2K3), transcript variant B
Alternative NameMAPKK3; MEK3; MKK3; PRKMK3; SAPKK-2; SAPKK2
Database LinkNP_659731
FunctionMAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis.
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway

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WB Image
Western blot analysis of MAP2K3 (arrow) using rabbit polyclonal MAP2K3 Antibody (S189) .293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAP2K3 gene (Lane 2) (Origene Technologies).
IHC Image
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with MAP2K3 Antibody (S189) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

 

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