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Anti-MAP2K3 Antibody EP555Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against MAP2K3 (Clone EP555Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403425) , 20ug Explanation
100ul $325 3-7 Days
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Also for MAP2K3 (NM_145109)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the N-terminus of human MKK3 was used as immunogen.
Clone NameEP555Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsIP: 1:50; WB: 1:5000 - 1:20000; FC: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC or IHC.

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase 3 (MAP2K3), transcript variant B
Alternative NameMAPKK3; MEK3; MKK3; PRKMK3; SAPKK-2; SAPKK2
Database LinkNP_659731
Entrez Gene 5606 Human
FunctionMitogen-acitvated protein kinase kinase 3 (MKK3) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). MKK3, closely related to MKK6, efficiently phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines and environmental stress but not JNK or ERK (3). MKK3 is activated by mitogenic and environ-mental stress stimulus as well as by insulin. MKK3 is necessary for the expression of glucose transporter and participates in the MAP kinase- mediated signaling cascade (4).
Related PathwayProtein KinaseTranscription FactorsDruggable Genome MAPK signaling pathwayToll-like receptor signaling pathwayFc epsilon RI signaling pathwayGnRH signaling pathwayAmyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - MEK3 antibody [EP555Y]; All lanes : Anti-MEK3 antibody [EP555Y] at 1/20000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Hela cell lysate.Lane 3 : MCF-7 cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 39 kDa.Observed band size : 40 kDa .


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