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Home Antibody All anti-MAP2K2 antibodies

Anti-MAP2K2 TRUEMAB Antibody Clone 5B4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA505762
  • MAP2K2 (MEK2 ) mouse monoclonal antibody, Clone 5B4
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403069) , 20ug Explanation
100ul 325 In Stock
CF505762
  • Carrier-free (BSA/glycerol-free) MAP2K2 mouse monoclonal antibody,clone 5B4
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(2)
IF(1)
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Also for MAP2K2 (NM_030662)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human MAP2K2(NP_109587) produced in HEK293T cell.
Clone NameClone 5B4 IsotypeIgG1
Species ReactivityHuman , Dog , Mouse Concentration1 mg/ml
Guaranteed Application *WB, IF Suggested Dilutions WB 1:200~2000, IF 1:100,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2)
Alternative NameCFC4; MAPKK2; MEK2; MKK2; PRKMK2
Database LinkNP_109587
Entrez Gene 5605 Human
Entrez Gene 26396 Mouse
Entrez Gene 611939 Dog
FunctionThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq].
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayErbB signaling pathwayVascular smooth muscle contractionVEGF signaling pathwayGap junctionToll-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MAP2K2 (RC201827, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MAP2K2.
WB Image
Western blot analysis of extracts (35ug) from 9 different cell lines by usin g anti-MAP2K2 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
IF Image
Anti-MAP2K2 mouse monoclonal antibody (TA505762) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MAP2K2(RC201827).

 

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