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Anti-MAP2K1 Antibody EPR2365Y
Also for MAP2K1 (NM_002755)
|A synthetic peptide corresponding to residues surrounding threonine 292 of human MEK1 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1)|
|CFC3; MAPKK1; MEK1; MKK1; PRKMK1|
|MEK1 and MEK2 (MAPK kinase 1/2, or ERK kinase 1/2) are mitogen-activated protein kinases that stimulate MAP kinase (MAPK) activity, playing a role in both cell growth and differentiation (1,2). MEK itself is activated via phosphorylation at serines 217/218 and 221/222 by upstream activator kinases, including c-raf, mos and MEK kinase (3,4). MEK1 and MEK2 are activated by a wide variety of growth factors and cytokines, and also by membrane depolarization and calcium influx (5). Activated MEK1 acts as a dual specificity kinase and phosphorylates both a threonine and a tyrosine residue on MAPK. In return, there is a feedback phosphorylation on MEK1 by MAPK on threonine 292 and 386. |
EGFR1 Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
Toll-like receptor signaling pathway
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Western blot - MEK1 ( T292) antibody [EPR2365Y]; All lanes : Anti-MEK1 (phospho T292) antibody [EPR2365Y] at 1/500 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HeLa cell lysate, treated with Nocodazole.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit-HRP at 1/1000 dilution.developed using the ECL technique.Predicted band size : 43 kDa.Observed band size : 43 kDa.