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Anti-MAP2K1 Antibody Y77
Also for MAP2K1 (NM_002755)
|A synthetic peptide corresponding to residues in C-terminus of human MEK1 was used as immunogen. The antibody does not cross-react with other MAP kinase kinase family members.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 10,000; IHC: 1:250; ICC: 1:250-1:500; FC: 1:40; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Does not react with Mouse, Rat
|Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1)|
|CFC3; MAPKK1; MEK1; MKK1; PRKMK1|
|MEK1 and MEK2 (MAPK kinase 1/2, or ERK kinase 1/2) are mitogen-activated protein kinases that stimulate MAP kinase activity, playing a role in both cell growth and differentiation (1,2). MEK itself is activated via phosphorylation at serines 217/218 and 221/222 by upstream activator kinases, including c-raf, mos and MEK kinase (3,4). MEK1 and MEK2 are activated by a wide variety of growth factors and cytokines, and also by membrane depolarization and calcium influx (5).|
EGFR1 Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
Toll-like receptor signaling pathway
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Western blot - MEK1 antibody [Y77]; Anti-MEK1 antibody [Y77] at 1/10000 dilution + Jurkat cell lysate.Predicted band size : 43 kDa.Observed band size : 45 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MEK1 antibody [Y77]; Ab32576, at a 1/250 dilution, staining MEK1 in urinary bladder carcinoma by IHC-P.