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Home Antibody All anti-MAP2K1 antibodies

Anti-MAP2K1 Antibody Y77

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300021
  • Rabbit Monoclonal Antibody against MAP2K1
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400974) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(1)
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Also for MAP2K1 (NM_002755)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in C-terminus of human MEK1 was used as immunogen. The antibody does not cross-react with other MAP kinase kinase family members.
Clone NameY77 IsotypeIgG
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 10,000; IHC: 1:250; ICC: 1:250-1:500; FC: 1:40; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1)
Alternative NameCFC3; MAPKK1; MEK1; MKK1; PRKMK1
Database LinkNP_002746
FunctionMEK1 and MEK2 (MAPK kinase 1/2, or ERK kinase 1/2) are mitogen-activated protein kinases that stimulate MAP kinase activity, playing a role in both cell growth and differentiation (1,2). MEK itself is activated via phosphorylation at serines 217/218 and 221/222 by upstream activator kinases, including c-raf, mos and MEK kinase (3,4). MEK1 and MEK2 are activated by a wide variety of growth factors and cytokines, and also by membrane depolarization and calcium influx (5).
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
MAPK signaling pathway
Melanogenesis
Senescence and Autophagy
Toll-like receptor signaling pathway

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WB Image
Western blot - MEK1 antibody [Y77]; Anti-MEK1 antibody [Y77] at 1/10000 dilution + Jurkat cell lysate.Predicted band size : 43 kDa.Observed band size : 45 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MEK1 antibody [Y77]; Ab32576, at a 1/250 dilution, staining MEK1 in urinary bladder carcinoma by IHC-P.

 

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